中文名称    细胞膜蛋白Derlin抗体    
英文名称    DERLIN-1
别    名    Derlin1; Derlin1; Derlin 1; DER1; DER-1; DER 1; DERL1_HUMAN.      
研究领域    细胞生物  细胞膜蛋白      
抗体来源    Rabbit    
克隆类型    Polyclonal    
交叉反应    Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,     
产品应用    ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    
分 子 量    29kDa    
细胞定位    细胞浆 细胞膜     
性    状    Lyophilized or Liquid    
浓    度    1mg/ml    
免 疫 原    KLH conjugated synthetic peptide derived from human DERLIN-1:111-220/251     
亚    型    IgG    
纯化方法    affinity purified by Protein A    
储 存 液    0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.    
保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

产品介绍    Degradation in endoplasmic reticulum proteins, also designated Derlins or DERtrins, are crucial for the degradation of misfolded endoplasmic reticulum (ER) luminal proteins. Derlin proteins are multi-pass membrane proteins localizing to the ER. Derlins are involved in transferring misfolded proteins from the ER to the cytosol, where the misfolded proteins are destroyed in an ubiquitin-dependent manner by the proteasome. In the case of cytomegalovirus infection, Derlin-1, as opposed to Derlins-2 and -3, is involved in the export of MHC class I heavy chains from the ER via its interaction with the viral protein US11. Derlins may also be important for cell proliferation.