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ACQUITY UPLC CSH C18 Column
面议
ACQUITY UPLC CSH Phenyl-Hexyl Column
面议
ACQUITY UPLC HSS T3 Column
面议
ACQUITY UPLC HSS PFP Column
面议
ACQUITY UPLC BEH HILIC柱
面议
ACQUITY UPLC BEH Shield RP18 Column
面议
ACQUITY UPLC BEH Phenyl Column
面议
ACQUITY UPLC BEH Amide Column
面议
ACQUITY UPLC HSS Cyano Column
面议
ACQUITY UPLC系统
面议
Alliance HPLC系统
面议
Breeze QS HPLC系统
面议与CORTECS，CSH和BEH颗粒相比，ACQUITY UPLC HSS色谱柱为极性与非极性分析物提供更理想、更平衡的保留效果。经过工艺优化的硅胶颗粒，其机械强度与稳定性更能耐受。UPLC系统操作压力。5种差异较大的键合相，提供更宽泛的选择空间，除了传统的疏水反相保留机理之外，还有偶极-偶极、芳香与氢键相互作用。
ACQUITY UPLC HSS C18 SB色谱柱是一种未封端、低覆盖度硅胶基质C18化学，可为受硅醇基作用影响的化合物提供其它选择性。HSS C18 SB色谱柱硅醇活性提高，使得碱性化合物的保留更强(由于与残留硅醇基的次级作用)，同时降低了对非碱性分析物的保留
(由于其低配体密度以及离子推斥性)。该保留特征的组合产生了一种有用的方法开发工具，可为碱性分析物提供不同的选择性(SB：Selectivity for Bases)，同时还可保持优异峰形。
A rapid and simple LC-MS/MS method was developed and validated for the simultaneous estimation of sofosbuvir (SF) and its metabolite GS-331007 (GS) using famotidine as an internal standard (IS). The Xevo TQD LC-MS/MS was operated under the multiple-reaction monitoring mode using electrospray ionization. Extraction with ethyl acetate was used in sample preparation. The prepared samples were chromatographed on Acquity UPLC HSS C18 (50 mm × 2.1 mm, 1.8 μm) column by pumping 0.1% formic acid and acetonitrile (50:50, v/v) in an isocratic mode at a flow rate of 0.3 ml/min. Method validation was performed as per the FDA guidelines and the standard curves were found to be linear in the range of 10–2500 ng/ml for both SF and its metabolite. The intra-day and inter-day precision and accuracy results were within the acceptable limits. A very short run time of 1.2 min made it possible to analyze more than 300 human plasma samples per day. The developed assay method was successfully applied to a bioequivalence study in human volunteers.
品名 | 编号 |
ACQUITY - Xselect HSS C18 Method Transfer Kit, 100Å, 1.8 - 5 µm, 2.1 - 4.6 mm X 50 - 100mm, 2/pkg | 186004968 |
ACQUITY - Xselect HSS C18 Method Transfer Kit, 100Å, 1.8 - 5 µm, 2.1 - 4.6 mm X 50 - 150mm, 2/pkg | 186004961 |
ACQUITY - Xselect HSS C18 SB Method Transfer Kit, 100Å, 1.8 - 3.5 µm, 2.1 - 4.6 mm X 50 - 100mm, 2... | 186004970 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 1 mm X 100 mm, 1/pkg | 186003530 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 1 mm X 150 mm, 1/pkg | 186003531 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 3 mm X 30 mm, 3/pkg | 176001817 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 3 mm X 50 mm, 3/pkg | 176001818 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 3 mm X 100 mm, 3/pkg | 176001819 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 1 mm X 50 mm, 3/pkg | 176001121 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 2.1 mm X 30 mm, 3/pkg | 176001398 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 2.1 mm X 150 mm, 3/pkg | 176001126 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 1 mm X 100 mm, 3/pkg | 176001122 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 1 mm X 150 mm, 3/pkg | 176001123 |
ACQUITY UPLC HSS C18 Method Validation Kit, 100Å, 1.8 µm, 2.1 mm X 150 mm, 3/pkg | 186006026 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 2.1 mm X 50 mm, 3/pkg | 176001124 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 2.1 mm X 100 mm, 3/pkg | 176001125 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 2.1 mm X 150 mm, 1/pkg | 186003534 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 2.1 mm X 100 mm, 1/pkg | 186003533 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 2.1 mm X 30 mm, 1/pkg | 186003987 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 2.1 mm X 50 mm, 1/pkg | 186003532 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 3 mm X 30 mm, 1/pkg | 186004682 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 3 mm X 50 mm, 1/pkg | 186004683 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 3 mm X 100 mm, 1/pkg | 186004684 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 3 mm X 150 mm, 1/pkg | 186004685 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 3 mm X 75 mm, 1/pkg | 186005618 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 2.1 mm X 75 mm, 1/pkg | 186005615 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 3 mm X 150 mm, 3/pkg | 176001820 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 1 mm X 50 mm, 1/pkg | 186003529 |
ACQUITY UPLC HSS C18 VanGuard Pre-column, 100Å, 1.8 µm, 2.1 mm X 5 mm, 3/pkg | 186003981 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 3 mm X 150 mm, 1/pkg | 186004689 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 2.1 mm X 30 mm, 3/pkg | 176001559 |
ACQUITY UPLC HSS C18 Method Validation Kit, 100Å, 1.8 µm, 2.1 mm X 50 mm, 3/pkg | 186004057 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 1 mm X 50 mm, 3/pkg | 176001556 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 1 mm X 100 mm, 3/pkg | 176001557 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 1 mm X 150 mm, 3/pkg | 176001558 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 3 mm X 100 mm, 1/pkg | 186004826 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 2.1 mm X 100 mm, 1/pkg | 186004119 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 2.1 mm X 30 mm, 1/pkg | 186004117 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 2.1 mm X 50 mm, 1/pkg | 186004118 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 1 mm X 100 mm, 1/pkg | 186004115 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 1 mm X 150 mm, 1/pkg | 186004116 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 3 mm X 30 mm, 1/pkg | 186004686 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 3 mm X 100 mm, 3/pkg | 176001823 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 2.1 mm X 75 mm, 1/pkg | 186005616 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 3 mm X 150 mm, 3/pkg | 176001824 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 2.1 mm X 150 mm, 1/pkg | 186004120 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 3 mm X 30 mm, 3/pkg | 176001821 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 2.1 mm X 150 mm, 3/pkg | 176001562 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 2.1 mm X 100 mm, 3/pkg | 176001561 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 2.1 mm X 50 mm, 3/pkg | 176001560 |
ACQUITY UPLC HSS C18 Method Validation Kit, 100Å, 1.8 µm, 3 mm X 100 mm, 3/pkg | 186004704 |
ACQUITY UPLC HSS C18 Method Validation Kit, 100Å, 1.8 µm, 3 mm X 50 mm, 3/pkg | 186004703 |
ACQUITY UPLC HSS C18 SB VanGuard Pre-column, 100Å, 1.8 µm, 2.1 mm X 5 mm, 3/pkg | 186004136 |
ACQUITY UPLC HSS C18 SB Method Validation Kit, 100Å, 1.8 µm, 2.1 mm X 150 mm, 3/pkg | 186006027 |
ACQUITY UPLC HSS C18 SB Method Validation Kit, 100Å, 1.8 µm, 2.1 mm X 50 mm, 3/pkg | 186004137 |
ACQUITY UPLC HSS C18 SB Method Validation Kit, 100Å, 1.8 µm, 2.1 mm X 100 mm, 3/pkg | 186004138 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 3 mm X 50 mm, 3/pkg | 176001822 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 3 mm X 75 mm, 1/pkg | 186005619 |
ACQUITY UPLC HSS C18 SB Method Validation Kit, 100Å, 1.8 µm, 3 mm X 50 mm, 3/pkg | 186004705 |
ACQUITY UPLC HSS C18 SB Method Validation Kit, 100Å, 1.8 µm, 3 mm X 100 mm, 3/pkg | 186004709 |
